This course is about enabling students to contribute professionally and/or scientifically through the next decades to the systemic design, engineering, analysis, planning, testing, implementation, operation, adaptation, and optimization of supply chain facilities and networks of such facilities. The course covers supply chain facilities such as logistic, deployment (e.g. warehousing), realization, and customer interface centers. Learning is aimed to be applicable in a wide variety of supply chain types, notably spanning e-commerce, healthcare, manufacturing, and retailing, concurrently subject to performance goals such as agility, efficiency, responsiveness, resiliency, scalability, and sustainability.