The course introduces juniors in BME to the field of computational systems biology.  It covers all typical aspects of biomathematical modeling, including: the choice of a modeling framework from among alternative approaches; the design of interaction diagrams; the identification of variables and processes; the design of systems models; standard methods of parameter estimation; the analysis of steady states, stability, sensitivity and gains; numerical evaluations of transients; phase-plane analysis; and the simulation of representative biomedical scenarios.  All theoretical concepts are exemplified with applications.